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Issue 35, 2018, Issue in Progress
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Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo

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Abstract

Based on N-cyclobutylaminoluciferin (cybLuc), a set of high and efficient caged bioluminescent derivatives (Clucs) as firefly luciferase pro-substrates has been developed herein. After careful examination, these molecules exhibited low cytotoxicity and prolonged bioluminescence imaging up to 6 h in vitro and in vivo. Importantly, these caged luciferin derivatives have the potential to serve as long-term tracking tools to explore some biological process by using bioluminescent imaging.

Graphical abstract: Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo

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Publication details

The article was received on 16 Mar 2018, accepted on 20 May 2018 and first published on 30 May 2018


Article type: Paper
DOI: 10.1039/C8RA02312C
RSC Adv., 2018,8, 19596-19599
  • Open access: Creative Commons BY license
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    Novel caged luciferin derivatives can prolong bioluminescence imaging in vitro and in vivo

    C. Zhang, M. Yuan, G. Han, Y. Gao, C. Tang, X. Li, L. Du and M. Li, RSC Adv., 2018, 8, 19596
    DOI: 10.1039/C8RA02312C

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