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Issue 41, 2018, Issue in Progress
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Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

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Abstract

Hybrid nanobiointerfaces were designed as an original contribution to the challenge of synthesizing nanostructured biomaterials integrating a set of cell fate-determining cues, originally provided to cells by the extracellular matrix (ECM). The produced biointerfaces consist of a stiff framework of intersected polypyrrole (PPy) nanotubes supporting a soft multilayer composed of ECM-derived biomacromolecules: collagen (Col) and hyaluronic acid (HA). PPy frameworks with highly tunable characteristics were synthesized through chemical oxidative polymerization of pyrrole monomers, templated within track-etched polycarbonate (PC) membranes featuring a network of intersected nanopores. PPy interfaces with a porosity of 80%, composed of nanotubes with an average diameter ranging from 40 to 300 nm, intersecting at an angle of 90°, were shown to be self-supported. These rigid PPy nanostructured interfaces were functionalized with a self-assembling (HA/Col) multilayer deposited via a layer-by-layer process. Biofunctionalized and unmodified PPy frameworks were both shown to promote sustained cell adhesion, therefore demonstrating the cytocompatibility of the engineered matrices. Such nanobiointerfaces, combining a mechanically-stable framework of tunable dimensions with a soft biopolymeric multilayer of highly versatile nature, pave the way towards cell-instructive biomaterials able to gather a wide range of cues guiding cell behavior. The developed self-supported structures could be used as a coating or as membranes bridging different tissues.

Graphical abstract: Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

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Supplementary files

Article information


Submitted
11 Jan 2018
Accepted
13 Jun 2018
First published
22 Jun 2018

This article is Open Access

RSC Adv., 2018,8, 22932-22943
Article type
Paper

Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

D. Lefèvre, J. Louvegny, M. Naudin, E. Ferain, C. Dupont-Gillain and S. Demoustier-Champagne, RSC Adv., 2018, 8, 22932
DOI: 10.1039/C8RA00325D

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