Jump to main content
Jump to site search

Issue 11, 2018
Previous Article Next Article

Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

Author affiliations

Abstract

We have developed a Pd-catalyzed direct dehydroxylative cyanation of phenols by employing an inexpensive food additive, potassium ferrocyanide (K4[Fe(CN)6]), as the cyanating reagent instead of highly toxic cyanide salts. This protocol provides a strategically distinct approach for the preparation of aryl nitriles in a safe, mild, convenient and practical manner.

Graphical abstract: Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

Back to tab navigation

Supplementary files

Article information


Submitted
19 Mar 2018
Accepted
24 Apr 2018
First published
24 Apr 2018

Org. Chem. Front., 2018,5, 1835-1839
Article type
Research Article

Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

C. Zhao, W. Fang, K. P. Rakesh and H. Qin, Org. Chem. Front., 2018, 5, 1835 DOI: 10.1039/C8QO00295A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements