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Issue 6, 2018
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Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions

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Abstract

Dirhodium(II)-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp3)–H amination and alkene aziridination reactions, the latter followed by a nucleophilic aziridine ring opening, are the key steps of this strategy.

Graphical abstract: Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions

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Supplementary files

Article information


Submitted
27 Sep 2017
Accepted
14 Dec 2017
First published
21 Dec 2017

Org. Chem. Front., 2018,5, 948-953
Article type
Research Article

Approach to pactamycin analogues using rhodium(II)-catalyzed alkene aziridination and C(sp3)–H amination reactions

R. Rodrigues, Y. Lazib, J. Maury, L. Neuville, D. Leboeuf, P. Dauban and B. Darses, Org. Chem. Front., 2018, 5, 948
DOI: 10.1039/C7QO00878C

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