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Issue 9, 2018

CO2-switchable response of protein microtubules: behaviour and mechanism

Author affiliations

Abstract

Recently, we proposed a small molecular “inducing ligand” strategy to assemble proteins into highly-ordered structures via dual non-covalent interactions, i.e. carbohydrate–protein interaction and dimerization of Rhodamine B. Using this approach, artificial protein microtubules were successfully constructed. In this study, we find that these microtubules exhibit a perfect CO2 responsiveness; assembly and disassembly of these microtubules were nicely controlled by the alternative passage of CO2 and N2. Upon the injection of CO2, a negative net-charged SBA turns into a neutral or positive net-charged SBA, which elongated, to some extent, the effective distance between SBA and Rhodamine B, resulting in the disassociation of the Rhodamine B dimer. Further experimental and simulation results reveal that the CO2-responsive mechanism differs from that of solubility change of the previously reported CO2-responsive synthetic materials.

Graphical abstract: CO2-switchable response of protein microtubules: behaviour and mechanism

Supplementary files

Article information


Submitted
17 May 2018
Accepted
22 Jun 2018
First published
25 Jun 2018

Mater. Chem. Front., 2018,2, 1642-1646
Article type
Research Article

CO2-switchable response of protein microtubules: behaviour and mechanism

G. Yang, R. Hu, H. Ding, Z. Kochovski, S. Mei, Y. Lu, Y. Ma, G. Chen and M. Jiang, Mater. Chem. Front., 2018, 2, 1642 DOI: 10.1039/C8QM00245B

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