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Issue 38, 2018
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Recent advances in β-lactam synthesis

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Abstract

During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis. Traditional methods for β-lactam synthesis usually involved amide bond formation and the Staudinger reaction. In recent years, by the advancement of photo- and transition metal-catalysis, several new methods have been reported for β-lactam synthesis. For instance: ligand assisted metal catalyzed C–H activation/intermolecular oxidative amidation draws attention for β-lactam synthesis. In this review we introduce methods for β-lactam synthesis and present newly developed reactions. We approach the synthesis of β-lactams according to different retro synthesis strategies.

Graphical abstract: Recent advances in β-lactam synthesis

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Article information


Submitted
30 Jul 2018
Accepted
04 Sep 2018
First published
04 Sep 2018

Org. Biomol. Chem., 2018,16, 6840-6852
Article type
Review Article

Recent advances in β-lactam synthesis

S. Hosseyni and A. Jarrahpour, Org. Biomol. Chem., 2018, 16, 6840
DOI: 10.1039/C8OB01833B

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