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Issue 33, 2018
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Integrating continuous flow synthesis with in-line analysis and data generation

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Abstract

Continuous flow synthesis of fine chemicals has successfully advanced from an academic niche area to a rapidly growing field of its own that directly impacts developments and applications in industrial settings. Whilst the numerous advantages of flow over batch processing are widely recognised and have led to a wider uptake of continuous flow synthesis within the community, we have reached a point where continuous flow synthesis has to transition from a stand-alone enabling technology to a readily integrated synthesis concept. Thus it is paramount to embrace a multitude of in-line analysis and purification techniques to not only allow for efficiently telescoped multi-step sequences but ultimately generate bioactivity data concomitantly on newly synthesised entities. This short review summarises the state of the art in this field and presents both challenges and opportunities that arise from this ambitious endeavour.

Graphical abstract: Integrating continuous flow synthesis with in-line analysis and data generation

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Article information


Submitted
18 Jun 2018
Accepted
24 Jul 2018
First published
31 Jul 2018

Org. Biomol. Chem., 2018,16, 5946-5954
Article type
Review Article

Integrating continuous flow synthesis with in-line analysis and data generation

M. Baumann, Org. Biomol. Chem., 2018, 16, 5946
DOI: 10.1039/C8OB01437J

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