Issue 7, 2018

gem-Diborylalkanes: recent advances in their preparation, transformation and application

Abstract

Recently, gem-diborylalkanes have attracted much attention as versatile building blocks and fundamental intermediates in organic synthesis, because they enable multiple C–C bond construction and further transformation at C–B bonds. Importantly, gem-diborylalkanes can be utilised as bisnucleophilic partners in a variety of chemo-selective C–C bond-forming reactions. This review describes recent developments in synthesising gem-diborylalkanes in complex molecules along with their chemical transformation. In the first part of the review the different synthetic approaches used to synthesise gem-diborylalkanes are described. In the second part, an overview of the chemoselective transformation of gem-diborylalkanes into various functionalized materials is discussed along with one-carbon homologation of diborylmethane via a selective uni- and bidirectional method.

Graphical abstract: gem-Diborylalkanes: recent advances in their preparation, transformation and application

Article information

Article type
Review Article
Submitted
02 Dec 2017
Accepted
21 Jan 2018
First published
22 Jan 2018

Org. Biomol. Chem., 2018,16, 1050-1064

gem-Diborylalkanes: recent advances in their preparation, transformation and application

R. Nallagonda, K. Padala and A. Masarwa, Org. Biomol. Chem., 2018, 16, 1050 DOI: 10.1039/C7OB02978K

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