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Issue 34, 2018
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Biocompatible crosslinked β-cyclodextrin nanoparticles as multifunctional carriers for cellular delivery

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Abstract

Nanoparticle-based biomedicine has received enormous attention for theranostic applications, as these systems are expected to overcome several drawbacks of conventional therapy. Herein, effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties are used as a versatile and powerful class of nanocarriers. We report the synthesis of a novel biocompatible and multifunctional material, entirely consisting of covalently crosslinked organic molecules. Specifically, β-cyclodextrin (CD) precursors were crosslinked with rigid organic linker molecules to obtain small (∼150 nm), thermally stable and highly water-dispersible nanoparticles with an accessible pore system containing β-CD rings. The nanoparticles can be covalently labeled with dye molecules to allow effective tracking in in vitro cell experiments. Rapid sugar-mediated cell-uptake kinetics were observed with HeLa cells, revealing exceptional particle uptake within only 30 minutes. Additionally, the particles could be loaded with different cargo molecules showing pH-responsive release behavior. Successful nuclei staining with Hoechst 33342 dye and effective cell killing with doxorubicin cargo molecules were demonstrated in live-cell experiments, respectively. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.

Graphical abstract: Biocompatible crosslinked β-cyclodextrin nanoparticles as multifunctional carriers for cellular delivery

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Article information


Submitted
25 Mar 2018
Accepted
14 Aug 2018
First published
16 Aug 2018

Nanoscale, 2018,10, 16284-16292
Article type
Paper

Biocompatible crosslinked β-cyclodextrin nanoparticles as multifunctional carriers for cellular delivery

S. Datz, B. Illes, D. Gößl, C. v. Schirnding, H. Engelke and T. Bein, Nanoscale, 2018, 10, 16284
DOI: 10.1039/C8NR02462F

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