Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 4, 2018
Previous Article Next Article

Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

Author affiliations

Abstract

Polydiacetylenic nanofibers (PDA-Nfs) obtained by photopolymerization of surfactant 1 were optimized for intracellular delivery of small interfering RNAs (siRNAs). PDA-Nfs/siRNA complexes efficiently silenced the oncogene Lim-1 in the renal cancer cells 786-O in vitro. Intraperitoneal injection of PDA-Nfs/siLim1 downregulated Lim-1 in subcutaneous tumor xenografts obtained with 786-O cells in nude mice. Thus, PDA-Nfs represent an innovative system for in vivo delivery of siRNAs.

Graphical abstract: Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

Back to tab navigation

Supplementary files

Article information


Submitted
11 Dec 2017
Accepted
25 Dec 2017
First published
03 Jan 2018

Nanoscale, 2018,10, 1587-1590
Article type
Communication

Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

P. Neuberg, I. Hamaidi, S. Danilin, M. Ripoll, V. Lindner, M. Nothisen, A. Wagner, A. Kichler, T. Massfelder and J.-S. Remy, Nanoscale, 2018, 10, 1587
DOI: 10.1039/C7NR09202D

Social activity

Search articles by author

Spotlight

Advertisements