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Issue 3, 2018
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Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles

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Abstract

The possibility of combining more than one stimulus-responsive property into a single material holds interesting potential for the creation of adaptive devices to be used in diverse fields such as drug delivery, nanomedicine and tissue engineering. This paper describes a novel material based on thermo-responsive PNIPAm nanopillars with amplified surface properties through the incorporation of Fe3O4 nanoparticles. The incorporation of magnetic nanoparticles into the nanopillars, prepared via surface-initiated atom-transfer radical polymerization in anodized aluminum oxide templates, sharply increased their stiffness and hydrophobicity when increasing the temperature above the volume phase transition temperature. Furthermore, their magnetic response turned out to be proportional to the amount of the incorporated nanoparticles. The possibility of sharply increasing the stiffness with a temperature variation close to the human body temperature paves the way to the application of these substrates as “smart” scaffolds for cell culture. Additionally, the presence of superparamagnetic nanoparticles in the nanopillars offers the possibility of using these nanostructured systems for magnetic hyperthermia.

Graphical abstract: Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles

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Article information


Submitted
20 Aug 2017
Accepted
06 Dec 2017
First published
06 Dec 2017

Nanoscale, 2018,10, 1189-1195
Article type
Paper

Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles

J. M. Giussi, C. von Bilderling, E. Alarcón, L. I. Pietrasanta, R. Hernandez, R. P. del Real, M. Vázquez, C. Mijangos, M. L. Cortez and O. Azzaroni, Nanoscale, 2018, 10, 1189
DOI: 10.1039/C7NR06209E

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