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Issue 3, 2018
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Constrained saccharides: a review of structure, biology, and synthesis

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Abstract

Review primarily covers from 1995–2018

Carbohydrate function, recognized in a multitude of biological processes, provides a precedent for developing carbohydrate surrogates that mimic the structure and function of bioactive compounds. In order to constrain highly flexible oligosaccharides, synthetic tethering techniques like those exemplified by stapled peptides are utilized to varying degrees of success. Naturally occurring constrained carbohydrates, however, exist with noteworthy cytotoxic and chemosensitizing properties. This review highlights the structure, biology, and synthesis of this intriguing class of molecules.

Graphical abstract: Constrained saccharides: a review of structure, biology, and synthesis

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Article information


Submitted
30 Oct 2017
First published
07 Mar 2018

Nat. Prod. Rep., 2018,35, 220-229
Article type
Review Article

Constrained saccharides: a review of structure, biology, and synthesis

J. Rodriguez, S. O'Neill and M. A. Walczak, Nat. Prod. Rep., 2018, 35, 220
DOI: 10.1039/C7NP00050B

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