Jump to main content
Jump to site search

Issue 18, 2018
Previous Article Next Article

Modulating the DNA cleavage ability of copper(ii) Schiff bases through ternary complex formation

Author affiliations


Copper(II) complexes with the potentially tridentate Schiff bases N-[(3-ethoxy-2-hydroxyphenyl)methylidene]-N′-tosylbenzene-1,2-diamine (H2L1) and N-[(2-hydroxynaphthanyl)methylidene]-N′-tosylbenzene-1,2-diamine (H2L2) have been synthesized by electrochemical oxidation of the metal in an electrochemical cell containing a solution of the corresponding ligand in acetonitrile. Adducts of these compounds with 2,2′-bipyridine (2,2′-bpy), 4,4′-bipyridine (4,4′-bpy) or 1,10-phenanthroline (phen) were also obtained. The complexes have been characterized by microanalysis, mass spectrometry, EPR, IR and UV-Vis spectroscopies, as well as DFT calculations. The ligand H2L1 and the compounds [CuL1(H2O)]·H2O (1), [Cu2L12(4,4′-bpy)] (3), [CuL1(phen)] (4), [CuL2(2,2′-bpy)] (6), and [Cu2L22(4,4′-bpy)3] (7) have also been characterized by X-ray diffraction. The copper compounds 1, 4 and 6 are mononuclear with a square planar geometry around the metal for 1 and square pyramidal for 4 and 6. However, 3 and 7 are dinuclear complexes with a 4,4′-bpy ligand bridging two copper atoms with square planar (3) or square pyramidal (7) coordination. The supramolecular structures were studied by means of Hirshfeld surface analysis. The adducts of phen and 2,2′-bpy exhibit enhanced DNA cleavage ability compared to the [CuL(H2O)] complexes (L = L1 or L2), while the binuclear entities formed by 4,4′-bpy coordination present reduced nuclease efficiency.

Graphical abstract: Modulating the DNA cleavage ability of copper(ii) Schiff bases through ternary complex formation

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Jul 2018, accepted on 09 Aug 2018 and first published on 09 Aug 2018

Article type: Paper
DOI: 10.1039/C8NJ03292K
New J. Chem., 2018,42, 15170-15183

  •   Request permissions

    Modulating the DNA cleavage ability of copper(II) Schiff bases through ternary complex formation

    J. Viqueira, M. L. Durán, J. A. García-Vázquez, J. Castro, C. Platas-Iglesias, D. Esteban-Gómez, G. Alzuet-Piña, A. Moldes and O. R. Nascimento, New J. Chem., 2018, 42, 15170
    DOI: 10.1039/C8NJ03292K

Search articles by author