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Issue 18, 2018
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A naphthalimide based fast and selective fluorescent probe for hypochlorous acid/hypochlorite and its application for bioimaging

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Abstract

A reversible and mitochondria targetable fluorescent probe (Nap-Se) bearing 1,8-naphthalimide and a selenomorpholine fragment was designed and synthesized. The probe showed a highly selective, sensitive and fast response (<2 s) toward hypochlorous acid/hypochlorite in phosphate buffer saline solution. Cell imaging studies confirmed that probe Nap-Se was specifically localized in mitochondria of living cells and could be used to monitor the levels of endogenous and exogenous HClO/ClO in RAW264.7 cells.

Graphical abstract: A naphthalimide based fast and selective fluorescent probe for hypochlorous acid/hypochlorite and its application for bioimaging

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Supplementary files

Article information


Submitted
28 Jun 2018
Accepted
06 Aug 2018
First published
07 Aug 2018

New J. Chem., 2018,42, 15105-15110
Article type
Paper

A naphthalimide based fast and selective fluorescent probe for hypochlorous acid/hypochlorite and its application for bioimaging

X. Lv, X. Yuan, Y. Wang and W. Guo, New J. Chem., 2018, 42, 15105
DOI: 10.1039/C8NJ03208D

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