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Issue 5, 2018
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Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

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Abstract

The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.

Graphical abstract: Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

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Article information


Submitted
14 Mar 2018
Accepted
07 Apr 2018
First published
20 Apr 2018

Med. Chem. Commun., 2018,9, 827-830
Article type
Research Article

Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

O. Koniev, I. Dovgan, B. Renoux, A. Ehkirch, J. Eberova, S. Cianférani, S. Kolodych, S. Papot and A. Wagner, Med. Chem. Commun., 2018, 9, 827
DOI: 10.1039/C8MD00141C

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