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Issue 10, 2018
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Inspiring process innovation via an improved green manufacturing metric: iGAL

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Abstract

Following our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved ‘innovation Green Aspiration Level’ (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes encompassing 703 steps across 12 companies, we find that iGAL affords an excellent proxy for molecular complexity and presents a valuable molecular weight-based ‘fixed’ goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.

Graphical abstract: Inspiring process innovation via an improved green manufacturing metric: iGAL

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Supplementary files

Article information


Submitted
24 Feb 2018
Accepted
21 Mar 2018
First published
28 Mar 2018

Green Chem., 2018,20, 2206-2211
Article type
Communication

Inspiring process innovation via an improved green manufacturing metric: iGAL

F. Roschangar, Y. Zhou, D. J. C. Constable, J. Colberg, D. P. Dickson, P. J. Dunn, M. D. Eastgate, F. Gallou, J. D. Hayler, S. G. Koenig, M. E. Kopach, D. K. Leahy, I. Mergelsberg, U. Scholz, A. G. Smith, M. Henry, J. Mulder, J. Brandenburg, J. R. Dehli, D. R. Fandrick, K. R. Fandrick, F. Gnad-Badouin, G. Zerban, K. Groll, P. T. Anastas, R. A. Sheldon and C. H. Senanayake, Green Chem., 2018, 20, 2206
DOI: 10.1039/C8GC00616D

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