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Issue 8, 2018
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Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

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Abstract

The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (∼30–40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.

Graphical abstract: Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

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Supplementary files

Article information


Submitted
01 Jan 2018
Accepted
08 Mar 2018
First published
03 Apr 2018

This article is Open Access

Green Chem., 2018,20, 1754-1759
Article type
Communication

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

K. Plasch, G. Hofer, W. Keller, S. Hay, D. J. Heyes, A. Dennig, S. M. Glueck and K. Faber, Green Chem., 2018, 20, 1754
DOI: 10.1039/C8GC00008E

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