Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2018
Previous Article Next Article

Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach

Author affiliations

Abstract

Squaraine dyes, that exhibit intense absorption in the red/near infrared region, have been successfully introduced into mesoporous silica nanoparticles (MSNs) to obtain a nanoplatform for photodynamic therapy. Three brominated squaraine dyes which exhibited good PS performance in solution but a different behaviour in vitro due to cell permeability issues were used as photosensitizers. The effects of the adsorption within the pores of MSNs on the overall UV-Vis-NIR absorption and emission properties as well as on the PS performance was evaluated via a combined experimental and computational physico-chemical approach, which allowed us to correlate the unusual optical properties of two out of three systems with the dimerization of squaraines on the silica surface, with detrimental effects on the PS performance. Conversely, the nanoplatform where the squaraine molecules are adsorbed as monomers on the silica surface exhibited the best activity in singlet oxygen generation.

Graphical abstract: Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach

Back to tab navigation

Supplementary files

Article information


Submitted
04 Oct 2017
Accepted
31 Oct 2017
First published
31 Oct 2017

Dalton Trans., 2018,47, 3038-3046
Article type
Paper

Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach

I. Miletto, A. Fraccarollo, N. Barbero, C. Barolo, M. Cossi, L. Marchese and E. Gianotti, Dalton Trans., 2018, 47, 3038
DOI: 10.1039/C7DT03735J

Social activity

Search articles by author

Spotlight

Advertisements