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Issue 10, 2018
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Tailoring lumazine synthase assemblies for bionanotechnology

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Abstract

Nanoscale compartments formed by hierarchical protein self-assembly are valuable platforms for nanotechnology development. The well-defined structure and broad chemical functionality of protein cages, as well as their amenability to genetic and chemical modification, have enabled their repurposing for diverse applications. In this review, we summarize progress in the engineering of the cage-forming enzyme lumazine synthase. This bacterial nanocompartment has proven to be a malleable scaffold. The natural protein has been diversified to afford a family of unique proteinaceous capsules that have been modified, evolved and assembled with other components to produce nanoreactors, artificial organelles, delivery vehicles and virus mimics.

Graphical abstract: Tailoring lumazine synthase assemblies for bionanotechnology

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Article information


Submitted
22 Feb 2018
First published
01 May 2018

Chem. Soc. Rev., 2018,47, 3543-3557
Article type
Review Article

Tailoring lumazine synthase assemblies for bionanotechnology

Y. Azuma, T. G. W. Edwardson and D. Hilvert, Chem. Soc. Rev., 2018, 47, 3543
DOI: 10.1039/C8CS00154E

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