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Issue 12, 2018
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Catalytic enantioselective aldol reactions

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Abstract

Recent developments in catalytic asymmetric aldol reactions have been summarized. Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl compounds in optical pure form, and as such, numerous successful chiral catalysts were designed and applied for asymmetric aldol reactions. This review article is organized under the categories of: (1) catalytic enantioselective aldol reactions of preformed enolates, (2) catalytic enantioselective direct-type aldol reactions using chiral metal catalysts, (3) catalytic enantioselective direct-type aldol reactions using organocatalysts, (4) catalytic enantioselective aldol reactions in aqueous media. Examples of the aldol reactions that employ simple carbonyl compounds will be also the focus of this review.

Graphical abstract: Catalytic enantioselective aldol reactions

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Article information


Submitted
03 Dec 2017
First published
30 May 2018

Chem. Soc. Rev., 2018,47, 4388-4480
Article type
Review Article

Catalytic enantioselective aldol reactions

Y. Yamashita, T. Yasukawa, W. Yoo, T. Kitanosono and S. Kobayashi, Chem. Soc. Rev., 2018, 47, 4388
DOI: 10.1039/C7CS00824D

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