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Issue 4, 2018
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Probing molecular forces in multi-component physiological membranes

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Abstract

Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Our molecular stress analysis could have far-reaching implications in describing the relationship between membrane mechanical properties and functional states of chemically distinct lipids.

Graphical abstract: Probing molecular forces in multi-component physiological membranes

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Article information


Submitted
01 Sep 2017
Accepted
17 Nov 2017
First published
27 Nov 2017

Phys. Chem. Chem. Phys., 2018,20, 2155-2161
Article type
Paper

Probing molecular forces in multi-component physiological membranes

A. Ray, F. Gräter and L. Thukral, Phys. Chem. Chem. Phys., 2018, 20, 2155
DOI: 10.1039/C7CP05981G

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