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Issue 27, 2018
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Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

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Abstract

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine–citric acid (CAFCA) and caffeine–glutaric acid (CAFGLU) cocrystals highlights the tunability of ILs in polymorphic control.

Graphical abstract: Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

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Supplementary files

Article information


Submitted
23 May 2018
Accepted
12 Jun 2018
First published
20 Jun 2018

This article is Open Access

CrystEngComm, 2018,20, 3817-3821
Article type
Communication

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

A. Mukherjee, R. D. Rogers and A. S. Myerson, CrystEngComm, 2018, 20, 3817 DOI: 10.1039/C8CE00859K

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