Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 20, 2018
Previous Article Next Article

Polar organometallic strategies for regioselective C–H metallation of N-heterocyclic carbenes

Author affiliations

Abstract

N-Heterocyclic carbenes (NHCs) have become indispensable ligands across a broad swathe of the synthetic and catalytic landscape, not in small part due to their ease of electronic and steric tunability. One of the latest additions to this important family of ligands are anionic NHCs, which have become valuable precursors to access abnormal NHC complexes as well as shown great potential for further NHC functionalisation. Deprotonative metallation has emerged as one of the most versatile methodologies to access anionic NHCs, where judicious choice of reaction conditions and metallating agents can finely tune the regioselectivity of the reaction. This Feature Article focuses on the recent emergence of s-block metal-mediated NHC metallations and the new opportunities this methodology offers.

Graphical abstract: Polar organometallic strategies for regioselective C–H metallation of N-heterocyclic carbenes

Back to tab navigation

Article information


Submitted
03 Jan 2018
Accepted
23 Jan 2018
First published
23 Jan 2018

Chem. Commun., 2018,54, 2455-2462
Article type
Feature Article

Polar organometallic strategies for regioselective C–H metallation of N-heterocyclic carbenes

M. Uzelac and E. Hevia, Chem. Commun., 2018, 54, 2455
DOI: 10.1039/C8CC00049B

Social activity

Search articles by author

Spotlight

Advertisements