Jump to main content
Jump to site search

Issue 13, 2018
Previous Article Next Article

A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

Author affiliations

Abstract

A peptide-based cell permeable synthetic transcription factor is reported, which binds to its target site with high affinity and specificity. When linked to a HAT-binding peptide, it causes significant upregulation of gene expression in a mammalian cell. Such molecules may be developed for selectively activating repressed genes in mammalian cells.

Graphical abstract: A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

Back to tab navigation

Supplementary files

Article information


Submitted
03 Dec 2017
Accepted
15 Jan 2018
First published
15 Jan 2018

Chem. Commun., 2018,54, 1611-1614
Article type
Communication

A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

K. Roy, A. Mazumder, P. Ghosh, G. Naiya, B. Ghosh and S. Roy, Chem. Commun., 2018, 54, 1611
DOI: 10.1039/C7CC09279B

Social activity

Search articles by author

Spotlight

Advertisements