Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 13, 2018
Previous Article Next Article

A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

Author affiliations

Abstract

A peptide-based cell permeable synthetic transcription factor is reported, which binds to its target site with high affinity and specificity. When linked to a HAT-binding peptide, it causes significant upregulation of gene expression in a mammalian cell. Such molecules may be developed for selectively activating repressed genes in mammalian cells.

Graphical abstract: A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

Back to tab navigation

Supplementary files

Article information


Submitted
03 Dec 2017
Accepted
15 Jan 2018
First published
15 Jan 2018

Chem. Commun., 2018,54, 1611-1614
Article type
Communication

A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

K. Roy, A. Mazumder, P. Ghosh, G. Naiya, B. Ghosh and S. Roy, Chem. Commun., 2018, 54, 1611
DOI: 10.1039/C7CC09279B

Social activity

Search articles by author

Spotlight

Advertisements