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Issue 99, 2018
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Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa

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Abstract

The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.

Graphical abstract: Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa

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Article information


Submitted
10 Oct 2018
Accepted
08 Nov 2018
First published
08 Nov 2018

Chem. Commun., 2018,54, 13929-13932
Article type
Communication

Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa

M. Purro, J. Qiao, Z. Liu, M. Ashcraft and M. P. Xiong, Chem. Commun., 2018, 54, 13929
DOI: 10.1039/C8CC08134D

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