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Issue 99, 2018
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Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa

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Abstract

The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.

Graphical abstract: Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa

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Publication details

The article was received on 10 Oct 2018, accepted on 08 Nov 2018 and first published on 08 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08134D
Chem. Commun., 2018,54, 13929-13932

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    Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa

    M. Purro, J. Qiao, Z. Liu, M. Ashcraft and M. P. Xiong, Chem. Commun., 2018, 54, 13929
    DOI: 10.1039/C8CC08134D

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