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Issue 83, 2018
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1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction

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Abstract

A novel 1,4-conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction has been developed. In this protocol, numerous carboxylic acids, ynamides and in situ generated ortho-quinone methides could assemble rapidly to constitute this process for the synthesis of functionalized 3,3-diarylpropanamides with sufficient structural diversity. Furthermore, the products could be transformed to an array of compounds.

Graphical abstract: 1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction

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Publication details

The article was received on 10 Sep 2018, accepted on 25 Sep 2018 and first published on 26 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07328G
Chem. Commun., 2018,54, 11753-11756

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    1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction

    R. Chen, Y. Liu and S. Cui, Chem. Commun., 2018, 54, 11753
    DOI: 10.1039/C8CC07328G

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