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Issue 81, 2018
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Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip

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Abstract

We designed an enzyme-activatable probe for real time in situ tracking of MT1-MMP activity. The MT1-MMP responses of endothelial cells were investigated under the regulation of shear stress and biochemical factor on a microfluidic chip. This strategy can be beneficial to evaluate membrane protein responses to external stimuli and to engineer cells for basic and clinical research.

Graphical abstract: Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip

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Publication details

The article was received on 01 Sep 2018, accepted on 17 Sep 2018 and first published on 17 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07117A
Chem. Commun., 2018,54, 11435-11438

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    Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip

    N. Li, W. Zhang, L. Lin, Z. He, M. Khan and J. Lin, Chem. Commun., 2018, 54, 11435
    DOI: 10.1039/C8CC07117A

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