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Issue 85, 2018
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Rh(iii)-Catalyzed ortho-C-(sp2)–H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis

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Abstract

Rh(III)-Catalyzed ortho-C–H amidation of ketones and aldehydes under cooperative metal organocatalysis has been utilized for synthesizing various ortho-amidocarbonyl analogs, and the reaction for the aldehyde proceeds at ambient temperature. The aniline derivative 3,5-bis(trifluoromethyl)aniline promotes the amidation reaction via a transient imine directing group. The efficient amidation agent is dioxazolone. The synthetic utility has been demonstrated in the synthesis of quindolinone alkaloids.

Graphical abstract: Rh(iii)-Catalyzed ortho-C-(sp2)–H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis

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Supplementary files

Article information


Submitted
29 Aug 2018
Accepted
26 Sep 2018
First published
26 Sep 2018

Chem. Commun., 2018,54, 12113-12116
Article type
Communication

Rh(III)-Catalyzed ortho-C-(sp2)–H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis

A. E. Hande, V. B. Ramesh and K. R. Prabhu, Chem. Commun., 2018, 54, 12113 DOI: 10.1039/C8CC07006G

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