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Issue 80, 2018
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Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

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Abstract

Heterocycles based on piperidine and pyrrolidine are key moieties in natural products and pharmaceutically active molecules. A novel multi-enzymatic approach based on the combination of a lipase with an α,ω-diamine transaminase is reported, opening up the synthesis, isolation and characterisation of a broad range of 2-substituted N-heterocycle alkaloids.

Graphical abstract: Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

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Article information


Submitted
20 Aug 2018
Accepted
17 Sep 2018
First published
17 Sep 2018

Chem. Commun., 2018,54, 11316-11319
Article type
Communication

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

J. L. Galman, I. Slabu, F. Parmeggiani and N. J. Turner, Chem. Commun., 2018, 54, 11316
DOI: 10.1039/C8CC06759G

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