Issue 93, 2018
From the journal:

Chemical Communications

Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation

Marta Jakubaszek, ORCID logo ab   Bruno Goud, ORCID logo b   Stefano Ferrari ORCID logo c  and  Gilles Gasser ORCID logo *a  

* Corresponding authors

a Chimie ParisTech, PSL University, Laboratory for Inorganic Chemical Biology, Paris, France
E-mail: gilles.gasser@chimieparistech.psl.eu
Web: http://www.gassergroup.com
Tel: +33 1 44 27 56 02

b Institut Curie, PSL University, CNRS UMR 144, Paris, France

c Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland

Abstract

The unique photophysical properties of Ru(II) polypyridyl complexes make them very attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date, there are not many studies exploring in detail the mechanism(s) of action of such compounds in living systems upon light irradiation. This feature article provides an overview of the most in-depth biological studies on such compounds.

Graphical abstract: Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation

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Article information

DOI
https://doi.org/10.1039/C8CC05928D
Article type
Feature Article
Submitted
21 Jul 2018
Accepted
22 Oct 2018
First published
23 Oct 2018

Chem. Commun., 2018,54, 13040-13059

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Mechanisms of action of Ru(II) polypyridyl complexes in living cells upon light irradiation

M. Jakubaszek, B. Goud, S. Ferrari and G. Gasser, Chem. Commun., 2018, 54, 13040 DOI: 10.1039/C8CC05928D

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