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Issue 82, 2018
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Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

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Abstract

We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.

Graphical abstract: Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

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Article information


Submitted
18 Jul 2018
Accepted
28 Aug 2018
First published
05 Sep 2018

Chem. Commun., 2018,54, 11538-11541
Article type
Communication

Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

N. L. Fletcher, Z. H. Houston, J. D. Simpson, R. N. Veedu and K. J. Thurecht, Chem. Commun., 2018, 54, 11538
DOI: 10.1039/C8CC05831H

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