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Issue 83, 2018
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Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

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Abstract

We studied the effect of subtle changes in side-chain chemistry and labelling with near infrared fluorophores of nanogels (NGs) prepared from thiolated poly(glycidol) on in vivo biodistribution in mice bearing human breast tumor xenografts. The stability and amphiphilic character of the side chain as well as labelling clearly influenced tumor targeting and overall biodistribution.

Graphical abstract: Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

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Article information


Submitted
12 Jul 2018
Accepted
19 Sep 2018
First published
27 Sep 2018

Chem. Commun., 2018,54, 11777-11780
Article type
Communication

Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

I. Zilkowski, I. Theodorou, K. Albrecht, F. Ducongé and J. Groll, Chem. Commun., 2018, 54, 11777
DOI: 10.1039/C8CC05627G

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