Issue 83, 2018

Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

Abstract

We studied the effect of subtle changes in side-chain chemistry and labelling with near infrared fluorophores of nanogels (NGs) prepared from thiolated poly(glycidol) on in vivo biodistribution in mice bearing human breast tumor xenografts. The stability and amphiphilic character of the side chain as well as labelling clearly influenced tumor targeting and overall biodistribution.

Graphical abstract: Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2018
Accepted
19 Sep 2018
First published
27 Sep 2018

Chem. Commun., 2018,54, 11777-11780

Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

I. Zilkowski, I. Theodorou, K. Albrecht, F. Ducongé and J. Groll, Chem. Commun., 2018, 54, 11777 DOI: 10.1039/C8CC05627G

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