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Issue 88, 2018
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Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

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Abstract

We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner.

Graphical abstract: Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

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Publication details

The article was received on 05 Jul 2018, accepted on 15 Oct 2018 and first published on 16 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC05405C
Chem. Commun., 2018,54, 12507-12510
  • Open access: Creative Commons BY license
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    Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

    D. Bermejo-Velasco, G. N. Nawale, O. P. Oommen, J. Hilborn and O. P. Varghese, Chem. Commun., 2018, 54, 12507
    DOI: 10.1039/C8CC05405C

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