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Issue 68, 2018
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Development of a novel inducer of protein–protein interactions based on aplyronine A†

Takayuki Ohyoshi,a   Atsuhiro Takano,a   Mayu Namiki,a   Tomotaka Ogura,a   Yuto Miyazaki,a   Yuta Ebihara,a   Koichi Takeno,a   Ichiro Hayakawa ORCID logo *b  and  Hideo Kigoshi ORCID logo *a  
Author affiliations

* Corresponding authors

a Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571, Japan
E-mail: kigoshi@chem.tsukuba.ac.jp

b Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
E-mail: ichiro.hayakawa@okayama-u.ac.jp

Abstract

An aplyronine A–swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein–protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

Graphical abstract: Development of a novel inducer of protein–protein interactions based on aplyronine A

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Article information

https://doi.org/10.1039/C8CC04613A
Submitted
09 Jun 2018
Accepted
04 Aug 2018
First published
06 Aug 2018
Chem. Commun., 2018,54, 9537-9540
Article type
Communication
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Development of a novel inducer of protein–protein interactions based on aplyronine A

T. Ohyoshi, A. Takano, M. Namiki, T. Ogura, Y. Miyazaki, Y. Ebihara, K. Takeno, I. Hayakawa and H. Kigoshi, Chem. Commun., 2018, 54, 9537
DOI: 10.1039/C8CC04613A

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