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Issue 59, 2018
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A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

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Abstract

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π–π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.

Graphical abstract: A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

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Article information


Submitted
01 Jun 2018
Accepted
29 Jun 2018
First published
04 Jul 2018

Chem. Commun., 2018,54, 8218-8221
Article type
Communication

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

P. Cui, W. Zhuang, X. Hu, L. Xing, R. Yu, J. Qiao, Y. He, F. Li, D. Ling and H. Jiang, Chem. Commun., 2018, 54, 8218
DOI: 10.1039/C8CC04363A

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