A portal to a class of novel sultone-functionalized pyridines via an annulative SuFEx process employing earth abundant nickel catalysts

Abstract

An efficient nickel catalyzed annulative process for the synthesis of a class of structurally unique heterocycles containing pharmaceutically important moieties of both pyridines and sultones was developed by using SuFEx chemistry. This mild and efficient method features a wide scope to serve as an irreplaceable asset for medicinal chemistry and drug discovery.