Jump to main content
Jump to site search

Issue 54, 2018
Previous Article Next Article

Pd(ii)-Catalyzed gamma-C(sp3)–H alkynylation of amides: selective functionalization of R chains of amides R1C(O)NHR

Author affiliations

Abstract

The gamma C(sp3)–H bond alkynylation of R chains of amides R1C(O)NHR, a fundamental class of synthetic substrates, has not been accomplished to date. Here, the first example of palladium(II)-catalyzed alkynylation of an unactivated gamma C(sp3)–H bond of alkyl amides (cyclic, linear, and amino acids) is reported. The kinetic experiment shows that the rate of the reaction depends on the coupling partners and the amides. Late-stage diversification of alkynylated amides was developed by utilizing amine and alkyne functionalities.

Graphical abstract: Pd(ii)-Catalyzed gamma-C(sp3)–H alkynylation of amides: selective functionalization of R chains of amides R1C(O)NHR

Back to tab navigation

Supplementary files

Article information


Submitted
27 Apr 2018
Accepted
08 Jun 2018
First published
08 Jun 2018

Chem. Commun., 2018,54, 7483-7486
Article type
Communication

Pd(II)-Catalyzed gamma-C(sp3)–H alkynylation of amides: selective functionalization of R chains of amides R1C(O)NHR

V. G. Landge, A. Parveen, A. Nandakumar and E. Balaraman, Chem. Commun., 2018, 54, 7483
DOI: 10.1039/C8CC03445A

Social activity

Search articles by author

Spotlight

Advertisements