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Issue 56, 2018
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Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

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Abstract

Enantiomeric carbon dots (C-dots) synthesized from L-lysine or D-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, L-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.

Graphical abstract: Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

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Publication details

The article was received on 23 Apr 2018, accepted on 20 Jun 2018 and first published on 22 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03235A
Chem. Commun., 2018,54, 7762-7765

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    Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

    R. Malishev, E. Arad, S. K. Bhunia, S. Shaham-Niv, S. Kolusheva, E. Gazit and R. Jelinek, Chem. Commun., 2018, 54, 7762
    DOI: 10.1039/C8CC03235A

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