Jump to main content
Jump to site search

Issue 39, 2018
Previous Article Next Article

Synthesis of 2-arylbenzofuran-3-carbaldehydes via an organocatalytic [3+2] annulation/oxidative aromatization reaction

Author affiliations

Abstract

A novel organocatalytic [3+2] annulation/oxidative aromatization reaction of enals with 2-halophenols or β-naphthols is reported. This process enables chemo- and regioselective access to 2-arylbenzofuran-3-carbaldehydes without the use of transition metals or strong oxidants. Preliminary mechanistic studies reveal that an unprecedented, organocatalytic, direct α-arylation pathway is involved.

Graphical abstract: Synthesis of 2-arylbenzofuran-3-carbaldehydes via an organocatalytic [3+2] annulation/oxidative aromatization reaction

Back to tab navigation

Supplementary files

Article information


Submitted
27 Mar 2018
Accepted
18 Apr 2018
First published
19 Apr 2018

Chem. Commun., 2018,54, 4935-4938
Article type
Communication

Synthesis of 2-arylbenzofuran-3-carbaldehydes via an organocatalytic [3+2] annulation/oxidative aromatization reaction

H. Zhang, C. Ma, Z. Zheng, R. Sun, X. Yu and J. Zhao, Chem. Commun., 2018, 54, 4935
DOI: 10.1039/C8CC02474J

Social activity

Search articles by author

Spotlight

Advertisements