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Issue 48, 2018
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Optochemical control of gene expression by photocaged guanine and riboswitches

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Abstract

Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.

Graphical abstract: Optochemical control of gene expression by photocaged guanine and riboswitches

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Supplementary files

Article information


Submitted
22 Mar 2018
Accepted
18 May 2018
First published
30 May 2018

This article is Open Access

Chem. Commun., 2018,54, 6181-6183
Article type
Communication

Optochemical control of gene expression by photocaged guanine and riboswitches

V. Dhamodharan, Y. Nomura, M. Dwidar and Y. Yokobayashi, Chem. Commun., 2018, 54, 6181
DOI: 10.1039/C8CC02290A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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