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Issue 32, 2018
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An intramolecular antiparallel G-quadruplex formed by human telomere RNA

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Abstract

Until now, RNA G-quadruplexes were believed to only adopt a parallel G-quadruplex structure. In this study, we describe the first observation of an antiparallel RNA G-quadruplex formed by human telomere RNA. This newly described topology is of great interest as it shows that RNA G-quadruplexes can also be polymorphic and adopt structures that are different from the parallel configuration.

Graphical abstract: An intramolecular antiparallel G-quadruplex formed by human telomere RNA

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Supplementary files

Article information


Submitted
20 Feb 2018
Accepted
26 Mar 2018
First published
27 Mar 2018

Chem. Commun., 2018,54, 3944-3946
Article type
Communication

An intramolecular antiparallel G-quadruplex formed by human telomere RNA

C. Xiao, T. Shibata, Y. Yamamoto and Y. Xu, Chem. Commun., 2018, 54, 3944
DOI: 10.1039/C8CC01427B

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