Issue 23, 2018

Construction of tunable peptide nucleic acid junctions


We report here the construction of 3-way and 4-way peptide nucleic acid (PNA) junctions as basic structural units for PNA nanostructuring. The incorporation of amino acid residues into PNA chains makes PNA nanostructures with more structural complexity and architectural flexibility possible, as exemplified by building 3-way PNA junctions with tunable nanopores. Given that PNA nanostructures have good thermal and enzymatic stabilities, they are expected to have broad potential applications in biosensing, drug delivery and bioengineering.

Graphical abstract: Construction of tunable peptide nucleic acid junctions

Supplementary files

Article information

Article type
05 Jan 2018
12 Jan 2018
First published
19 Jan 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 2846-2849

Construction of tunable peptide nucleic acid junctions

T. Duan, L. He, Y. Tokura, X. Liu, Y. Wu and Z. Shi, Chem. Commun., 2018, 54, 2846 DOI: 10.1039/C8CC00108A

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