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Issue 16, 2018
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Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers

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Abstract

Homo-oligomers of the natural product oxetin (cis-3-amino-2-oxetanecarboxylic acid) were prepared and their conformational behaviour studied in solution and solid state and by molecular modelling. The predominant secondary structure was a 10-helix, propiciously stabilized by a network of 5-membered ring H-bonds implicating ring oxygens and neighboring amide hydrogen atoms.

Graphical abstract: Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers

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Submitted
31 Dec 2017
Accepted
30 Jan 2018
First published
30 Jan 2018

Chem. Commun., 2018,54, 1968-1971
Article type
Communication

Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers

S. S. Ragab, A. F. Kassir, R. Guillot, M. Scherrmann, T. Boddaert and D. J. Aitken, Chem. Commun., 2018, 54, 1968
DOI: 10.1039/C7CC09964A

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