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Issue 22, 2018
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Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

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Abstract

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

Graphical abstract: Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

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Supplementary files

Article information


Submitted
20 Dec 2017
Accepted
22 Feb 2018
First published
22 Feb 2018

This article is Open Access

Chem. Commun., 2018,54, 2792-2795
Article type
Communication

Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

I. Abánades Lázaro, S. Abánades Lázaro and R. S. Forgan, Chem. Commun., 2018, 54, 2792
DOI: 10.1039/C7CC09739E

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