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Issue 15, 2018
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Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

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Abstract

Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.

Graphical abstract: Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

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Publication details

The article was received on 08 Sep 2017, accepted on 26 Jan 2018 and first published on 30 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC07048A
Chem. Commun., 2018,54, 1897-1900

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    Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

    C. Saintomé, P. Alberti, N. Guinot, P. Lejault, J. Chatain, P. Mailliet, J.-F. Riou and A. Bugaut, Chem. Commun., 2018, 54, 1897
    DOI: 10.1039/C7CC07048A

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