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Issue 5, 2018
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Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

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Abstract

Temperature-responsive cell culture substrates reported here can be dynamically programmed to induce bulk softening and surface roughness changes in the presence of living cells. Alterations in hepatocellular function following temporally controlled substrate softening depend on the extent of stiff mechanical priming prior to user-induced material transition.

Graphical abstract: Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

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Supplementary files

Article information


Submitted
13 Jan 2018
Accepted
06 Mar 2018
First published
09 Mar 2018

Biomater. Sci., 2018,6, 1002-1006
Article type
Communication

Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

K. Uto, T. Aoyagi, C. A. DeForest and M. Ebara, Biomater. Sci., 2018, 6, 1002
DOI: 10.1039/C8BM00047F

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