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Issue 30, 2018
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Detection of bisphenol A and derivatives in human urine via cyclodextrin-promoted fluorescence modulation

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Abstract

Reported herein is the sensitive and selective detection of bisphenol A (BPA) and six BPA derivatives in buffer and urine environments. This detection system relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold to promote highly analyte-specific, proximity-induced fluorescence modulation of high quantum yield fluorophores, which led to unique modulation responses for each cyclodextrin–analyte–fluorophore combination investigated in both buffer and urine environments, and high selectivity between structurally similar analytes using linear discriminant analysis of the resulting response signals. This method was sensitive (low micromolar detection limits), selective (able to differentiate between structurally similar analytes), and broadly applicable (with successful detection in both buffer and urine environments), and has significant potential in the detection of BPA and its derivatives in a wide variety of complex environments.

Graphical abstract: Detection of bisphenol A and derivatives in human urine via cyclodextrin-promoted fluorescence modulation

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Supplementary files

Article information


Submitted
02 Apr 2018
Accepted
06 Jul 2018
First published
10 Jul 2018

Anal. Methods, 2018,10, 3783-3790
Article type
Paper

Detection of bisphenol A and derivatives in human urine via cyclodextrin-promoted fluorescence modulation

D. J. DiScenza, J. Lynch, E. Feder and M. Levine, Anal. Methods, 2018, 10, 3783
DOI: 10.1039/C8AY00733K

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