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Issue 32, 2018
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Identification of proteins and bacteria based on a metal ion–gold nanocluster sensor array

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Abstract

We report a simple fluorescence sensor array based on metal ions–gold nanoclusters (AuNCs) for the identification of proteins and bacteria. In this study, three protein-stabilized AuNCs including BSA-AuNCs, HSA-AuNCs and Lys-AuNCs were firstly synthesized. After the purification of these protein@AuNCs by Zn2+ and Cd2+ respectively, six types of metal ion-protein@AuNCs were employed as the sensing elements to fabricate a fluorescence sensor array. In the presence of a protein, differential changes of fluorescence intensity on sensing elements generate a unique response pattern for the protein. In combination with linear discriminant analysis (LDA), 9 proteins with different concentrations were differentiated successfully. Moreover, 5 different bacteria were also identified by the proposed sensor array. The method is simple, rapid, and sensitive and shows potential for application in biomolecule sensing.

Graphical abstract: Identification of proteins and bacteria based on a metal ion–gold nanocluster sensor array

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Supplementary files

Article information


Submitted
16 Mar 2018
Accepted
06 Jul 2018
First published
09 Jul 2018

Anal. Methods, 2018,10, 3939-3944
Article type
Paper

Identification of proteins and bacteria based on a metal ion–gold nanocluster sensor array

Y. Wu, B. Wang, K. Wang and P. Yan, Anal. Methods, 2018, 10, 3939
DOI: 10.1039/C8AY00558C

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