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Issue 20, 2018
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In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

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Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

Graphical abstract: In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

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Supplementary files

Article information


Submitted
16 May 2018
Accepted
21 Jul 2018
First published
30 Jul 2018

This article is Open Access

Analyst, 2018,143, 4836-4839
Article type
Communication

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

O. Jonas, J. W. Kang, S. P. Singh, A. Lammers, F. T. Nguyen, R. R. Dasari, P. T. C. So, R. Langer and M. J. Cima, Analyst, 2018, 143, 4836
DOI: 10.1039/C8AN00913A

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