Antiviral activity of self-assembled glycodendrofullerene monoadducts†
A series of amphiphilic glycodendrofullerene monoadducts were efficiently synthesized using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self-assemble in aqueous media, in a process favoured through π–π interactions between the fullerene moieties. This aggregation process leads to big and well-defined compact micelles with a uniform size and spherical-shape. The supramolecular aggregates were characterized using electronic microscopy (SEM and TEM), light scattering methods (DLS) and X-ray methodologies (SAXS and XRD). The antiviral efficiency of these aggregates has been tested in an experimental infection assay using Ebola virus glycoprotein (EboGP) pseudotyped viral particles on Jurkat cells overexpressing DC-SIGN and an improvement in the IC50 value with respect to other systems endowed with a higher number of carbohydrate ligands is observed.
- This article is part of the themed collection: Carbon Nanostructures in Biology and Medicine